A 10-year-old girl has been experiencing symptoms of nasal congestion,watery eyes,and sneezing for the past 2 years.Percutaneous testing revealed that she was allergic to a number of antigens,including ragweed,grasses,dust mites,and cat dander.Treatment with over-the-counter drugs did not do much to alleviate her symptoms,which seemed to worsen with time.Her doctor prescribed allergy immunotherapy,and her symptoms began to improve over the next year.This therapy is thought to work through the administration of:

gradually increasing doses of the allergen over time to induce production of blocking IgG4 antibodies.

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