Which of the following statements is true of infection with hepatitis B? October 4, 2022 by 8i9x6 Anti-HBs is the first detectable antibody in serum. Anti-HBe is the first detectable antibody in serum. Anti-HBc is the first detectable antibody in serum. Anti-HBs, anti-HBe, and anti-HBc are detectable at the same time. See Answer Anti-HBc is the first detectable antibody in serum.